Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | FDPS | P14324 | 1/20 | 0.58 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.52 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.52 |
| ▸ | FABP1 | P07148 | 1/20 | 0.50 |
| ▸ | FABP6 | P51161 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5845328 | 1.00 | CYP2D6 (0.65) | CYP2D6ALDH1A1KDM4ESMN1; SMN2FDPS | |
| SCHEMBL7448193 | 0.85 | CYP2D6 (0.59) | CYP2D6ALDH1A1KDM4EFDPSPCSK9 | |
| SCHEMBL7471422 | 0.82 | CYP2D6 (0.61) | CYP2D6ALDH1A1KDM4EFDPSPCSK9 | |
| SCHEMBL7471428 | 0.82 | CYP2D6 (0.61) | CYP2D6ALDH1A1KDM4EFDPSPCSK9 | |
| SCHEMBL28657675 | 0.82 | CYP2C19 (0.56) | CYP2D6ALDH1A1KDM4EFDPSPCSK9 | |
| SCHEMBL1831588 | 0.81 | CYP2D6 (0.56) | CYP2D6ALDH1A1KDM4EFDPSPCSK9 | |
| SCHEMBL19935946 | 0.81 | CYP2D6 (0.56) | CYP2D6ALDH1A1KDM4EFDPSPCSK9 | |
| SCHEMBL14198659 | 0.81 | CYP2D6 (0.56) | CYP2D6ALDH1A1KDM4EFDPSPCSK9 | |
| SCHEMBL25387117 | 0.80 | PCSK9 (0.58) | CYP2D6ALDH1A1KDM4EFDPSPCSK9 | |
| SCHEMBL27773234 | 0.80 | CYP2D6 (0.63) | CYP2D6ALDH1A1KDM4EFDPSPCSK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133449-A | Processes and intermediates for the preparation of piperazine derivatives | JOHN WYETH & BROTHER LTD. (GB) | 2000-10-17 | — | — | US | claimed |
| EP-0763024-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1997-03-19 | — | — | EP | claimed |
| WO-1995033725-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1995-12-14 | — | — | WO | claimed |
| US-20040116709-A1 | Process for producing optically active n-aryl-1-amino-2-propanol derivatives | KANEKA CORPORATION (JP) | 2004-06-17 | — | — | US | disclosed |
| EP-1367053-A1 | PROCESS FOR PRODUCING OPTICALLY ACTIVE N-ARYL-1-AMINO-2-PROPANOL DERIVATIVES | KANEKA CORPORATION (JP) | 2003-12-03 | — | — | EP | disclosed |
| EP-0763024-B1 | PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIPERAZINE DERIVATIVES | WYETH JOHN & BROTHER LTD (GB) | 2002-08-14 | — | — | EP | disclosed |
| US-6395902-B1 | NOVEL INTERMEDIATES IN THE PREPARATION OF PHARMACEUTICALLY USEFUL PYRIDINE DERIVATIVES AS END COMPOUNDS | JOHN WYETH & BROTHER LIMITED (GB) | 2002-05-28 | — | — | US | disclosed |
| US-6175012-B1 | REACTING 4-METHYL-3-(2-PYRIDYL)-(1,2,3,)OXATHIAZOLIDINE-2,2-DIOXIDE, FOR EXAMPLE WITH A 1-(ARYL OR HETEROARYL)PIPERAZINE TO FORM A 1-(HETERO)ARYL-4-(HETEROARYLAMINOALKYL)PIPERAZINE; INTERMEDIATE TO 5-HT1A ANTAGONIST DRUGS | JOHN WYETH & BROTHER LTD. (GB) | 2001-01-16 | — | — | US | disclosed |
| US-6133449-A | Processes and intermediates for the preparation of piperazine derivatives | JOHN WYETH & BROTHER LTD. (GB) | 2000-10-17 | — | — | US | disclosed |
| EP-0763031-B1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 2000-05-10 | — | — | EP | disclosed |
| US-5723464-A | CENTRAL NERVOUS SYSTEM DISORDERS, ANXIETY OR DEPRESSION | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-03-03 | — | — | US | disclosed |
| EP-0770079-A1 | HETEROBICYCLIC DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-05-02 | — | — | EP | disclosed |
| EP-0763031-A1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1997-03-19 | — | — | EP | disclosed |
| EP-0763024-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033725-A1 | NOVEL PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF PIPERAZINE DERIVATIVES | JOHN WYETH & BROTHER LIMITED (GB) | 1995-12-14 | — | — | WO | disclosed |
| WO-1995033743-A1 | PIPERAZINE DERIVATIVES AS 5HT1A ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1995-12-14 | — | — | WO | disclosed |