Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679898 | 0.92 | RXRA (0.38) | EGFRCYP4F2CYP4A11RXRARXRB | |
| SCHEMBL680965 | 0.90 | RXRA (0.40) | EGFRCYP4F2CYP4A11RXRARXRB | |
| SCHEMBL679314 | 0.90 | RXRA (0.38) | EGFRCYP4F2CYP4A11RXRARXRB | |
| SCHEMBL680423 | 0.87 | EGFR (0.39) | EGFRCYP4F2CYP4A11RXRARXRB | |
| SCHEMBL680923 | 0.86 | CYP11B1 (0.40) | EGFRCYP4F2CYP4A11RXRARXRB | |
| SCHEMBL680130 | 0.86 | ATR (0.38) | EGFRRXRARXRBRXRGSCN9A | |
| SCHEMBL680305 | 0.85 | PLK4 (0.39) | EGFRCYP4F2CYP4A11RXRARXRB | |
| SCHEMBL680078 | 0.85 | CYP4F2 (0.34) | EGFRCYP4F2CYP4A11RXRARXRB | |
| SCHEMBL679358 | 0.85 | RXRA (0.41) | EGFRCYP4F2CYP4A11RXRARXRB | |
| SCHEMBL679359 | 0.85 | RXRA (0.41) | EGFRCYP4F2CYP4A11RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |