Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.33 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601521 | 0.85 | RXFP1 (0.39) | RXFP1KMT2ANCEH1ALDH1A1LMNA | |
| SCHEMBL6605932 | 0.84 | LMNA (0.38) | KMT2AGRIA2GRIN1GRIN2AALDH1A1 | |
| SCHEMBL6804459 | 0.83 | KMT2A (0.36) | RXFP1KMT2APTPN1ALDH1A1LMNA | |
| SCHEMBL6804138 | 0.82 | RXFP1 (0.36) | RXFP1KMT2ANCEH1ALDH1A1LMNA | |
| SCHEMBL6809755 | 0.81 | KMT2A (0.33) | RXFP1KMT2ANCEH1PTPN1 | |
| SCHEMBL6602524 | 0.81 | ADORA1 (0.40) | RXFP1KMT2ANCEH1S1PR4ALDH1A1 | |
| SCHEMBL6603187 | 0.80 | HTR2C (0.36) | RXFP1KMT2ANCEH1PTPN1ALDH1A1 | |
| SCHEMBL6603578 | 0.80 | RXFP1 (0.36) | RXFP1KMT2ANCEH1ALDH1A1LMNA | |
| SCHEMBL6602266 | 0.80 | KMT2A (0.34) | RXFP1KMT2ANCEH1ALDH1A1HTT | |
| SCHEMBL6606288 | 0.80 | RXFP1 (0.36) | RXFP1KMT2ANCEH1ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | BAYER PHARMACEUTICALS CORPORATION | 2004-09-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180891-A1 | Pyrazole derivatives useful in the treatment of hyper-proliferative disorders | MKI67, CDK4, FLT4 | RXFP1 3332/4885KMT2A 2911/4885NCEH1 3856/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.