Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 7/20 | 0.58 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.58 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6801004 | 1.00 | SPHK2 (0.58) | SPHK2SPHK1HRH3GAATRPV6 | |
| SCHEMBL9372352 | 0.92 | HRH3 (0.63) | SPHK2SPHK1HRH3TRPV6SIGMAR1 | |
| SCHEMBL6807049 | 0.92 | HRH3 (0.63) | SPHK2SPHK1HRH3TRPV6SIGMAR1 | |
| SCHEMBL6807045 | 0.92 | HRH3 (0.63) | SPHK2SPHK1HRH3TRPV6SIGMAR1 | |
| SCHEMBL9374317 | 0.88 | HRH3 (0.68) | SPHK2SPHK1HRH3TRPV6SIGMAR1 | |
| SCHEMBL9372055 | 0.88 | HRH3 (0.68) | SPHK2SPHK1HRH3TRPV6SIGMAR1 | |
| SCHEMBL9372067 | 0.88 | HRH3 (0.68) | SPHK2SPHK1HRH3TRPV6SIGMAR1 | |
| SCHEMBL20945190 | 0.80 | SPHK2 (0.76) | SPHK2SPHK1SIGMAR1 | |
| SCHEMBL18922677 | 0.78 | SPHK2 (0.63) | SPHK2SPHK1SIGMAR1 | |
| SCHEMBL9372378 | 0.78 | HRH3 (0.65) | SPHK2SPHK1HRH3GAATRPV6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1475373-A1 | 5,11-Dihydrodibenzo[b,e][1,4]-oxazepine derivatives as calcium channel antagonists | Ajinomoto Co., Inc. (JP) | 2004-11-10 | — | — | EP | disclosed |
| EP-1471060-A1 | 5,11-Dihydrodibenzo[b,e][1,4]-oxazepine derivatives as calcium channel antagonists | Ajinomoto Co., Inc. (JP) | 2004-10-27 | — | — | EP | disclosed |
| US-6528504-B2 | Compounds such as (R)-5,11-dihydro-5-(1-(4-methoxyphenethyl)-piperidine-2-ylmethyl) -dibenzo(b,e)(1,4) oxazepine are useful for treating or preventing abnormal motor functions of gastrointestinal tracts, e.g., irritable bowel syndrome. | AJINOMOTO CO., INC. (JP) | 2003-03-04 | — | — | US | disclosed |
| US-20020099047-A1 | Oxazepine derivatives and medicine containing the same | AJINOMOTO CO., INC. (JP) | 2002-07-25 | — | — | US | disclosed |
| EP-1142884-A1 | OXAZEPINE DERIVATIVES AND DRUGS CONTAINING THE SAME | Ajinomoto Co., Inc. (JP) | 2001-10-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020099047-A1 | Oxazepine derivatives and medicine containing the same | CACNG5, GRIK5, KCNB1 | SPHK2 734/4885SPHK1 960/4885HRH3 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.