Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MDM4 | O15151 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6795994 | 0.84 | CASP3 (0.57) | CASP3KMT2AMDM4TP53EPHX2 | |
| SCHEMBL119533 | 0.84 | CASP3 (0.61) | CASP3KMT2AMDM4TP53EPHX2 | |
| SCHEMBL29401028 | 0.84 | CASP3 (0.61) | CASP3KMT2AMDM4TP53EPHX2 | |
| SCHEMBL3201847 | 0.84 | CASP3 (0.61) | CASP3KMT2AMDM4TP53EPHX2 | |
| SCHEMBL31045969 | 0.84 | CASP3 (0.61) | CASP3KMT2AMDM4TP53EPHX2 | |
| SCHEMBL119762 | 0.84 | CASP3 (0.61) | CASP3KMT2AMDM4TP53EPHX2 | |
| SCHEMBL377860 | 0.80 | CASP3 (0.60) | CASP3KMT2AMDM4TP53EPHX2 | |
| SCHEMBL119194 | 0.80 | CASP3 (0.55) | CASP3KMT2AMDM4TP53SLC17A5 | |
| SCHEMBL30089284 | 0.80 | CASP3 (0.55) | CASP3KMT2AMDM4TP53SLC17A5 | |
| SCHEMBL25262883 | 0.79 | CASP3 (0.59) | CASP3KMT2AMDM4TP53EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6720338-B2 | BCL-X1 INHIBITING COMPOSITIONS AND METHODS OF PROMOTING APOPTOSIS IN A MAMMAL | ABBOTT LABORATORIES | 2004-04-13 | — | — | US | disclosed |