Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 12/20 | 0.57 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 3/20 | 0.46 |
| ▸ | PPARA | Q07869 | 3/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.46 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6423837 | 0.80 | SPHK1 (0.65) | SPHK1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL1855354 | 0.80 | ALDH1A1 (0.54) | SPHK1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL1313099 | 0.80 | ALDH1A1 (0.54) | SPHK1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL12117878 | 0.80 | NPC1 (0.54) | SPHK1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL6805184 | 0.80 | ALDH1A1 (0.54) | SPHK1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL6918608 | 0.78 | CHRM2 (0.42) | TPH1SPHK1KDM4ENPC1ALDH1A1 | |
| SCHEMBL28381546 | 0.78 | S1PR2 (0.60) | SPHK1KDM4EALDH1A1MAPTPKM | |
| SCHEMBL6805181 | 0.77 | MAPT (0.54) | SPHK1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL6715534 | 0.77 | MAPT (0.54) | SPHK1KDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL11338689 | 0.77 | ALDH1A1 (0.56) | SPHK1KDM4ENPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1470102-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | Applied Research Systems ARS Holding N.V. (AN) | 2004-10-27 | — | — | EP | disclosed |
| WO-2003064376-A1 | SUBSTITUTED METHYLENE AMIDE DERIVATIVES AS MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPS) | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2003-08-07 | — | — | WO | disclosed |