Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT3 | Q9Y243 | 7/20 | 0.36 |
| ▸ | AKT2 | P31751 | 6/20 | 0.36 |
| ▸ | AKT1 | P31749 | 5/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681566 | 0.90 | MEN1 (0.40) | AKT3AKT2AKT1CYP3A4MEN1 | |
| SCHEMBL680817 | 0.88 | AKT3 (0.39) | AKT3AKT2AKT1CYP3A4MEN1 | |
| SCHEMBL681791 | 0.88 | POLB (0.35) | HSD11B1POLB | |
| SCHEMBL681038 | 0.86 | AKT3 (0.35) | AKT3AKT2AKT1CYP3A4GAA | |
| SCHEMBL680141 | 0.86 | AKT3 (0.45) | AKT3AKT2AKT1GAAHPGD | |
| SCHEMBL684211 | 0.85 | BRD4 (0.41) | AKT3AKT2AKT1CYP3A4MEN1 | |
| SCHEMBL680114 | 0.85 | BRD4 (0.42) | AKT3AKT2AKT1CYP3A4MEN1 | |
| SCHEMBL681300 | 0.84 | AKT3 (0.47) | AKT3AKT2AKT1CYP3A4MEN1 | |
| SCHEMBL2739258 | 0.84 | AKT3 (0.38) | AKT3AKT2AKT1CYP3A4MEN1 | |
| SCHEMBL17803803 | 0.82 | AKT1 (0.48) | AKT3AKT2AKT1CYP3A4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |