Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680825 | 0.88 | POLB (0.38) | POLB | |
| SCHEMBL680199 | 0.88 | AKT3 (0.36) | POLBHSD11B1 | |
| SCHEMBL681788 | 0.86 | POLB (0.35) | POLBHSD11B1 | |
| SCHEMBL683339 | 0.85 | CYP1A2 (0.38) | POLB | |
| SCHEMBL2739041 | 0.84 | ALDH1A1 (0.37) | POLBHSD11B1 | |
| SCHEMBL681242 | 0.84 | AKT1 (0.37) | POLBHSD11B1 | |
| SCHEMBL681566 | 0.77 | MEN1 (0.40) | POLB | |
| SCHEMBL680817 | 0.76 | AKT3 (0.39) | POLB | |
| SCHEMBL681349 | 0.76 | POLB (0.39) | POLBHSD11B1 | |
| SCHEMBL679738 | 0.74 | POLB (0.38) | POLBHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |