Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 18/20 | 0.61 |
| ▸ | CCND1 | P24385 | 18/20 | 0.61 |
| ▸ | CCND2 | P30279 | 18/20 | 0.61 |
| ▸ | CCND3 | P30281 | 18/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 4/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 4/20 | 0.50 |
| ▸ | CDK2 | P24941 | 4/20 | 0.50 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.50 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.50 |
| ▸ | CDK1 | P06493 | 3/20 | 0.50 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5267373 | 0.91 | CDK4 (0.59) | CDK4CCND1CCND2CCND3CYP1A2 | |
| SCHEMBL6808803 | 0.87 | CDK4 (0.55) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL6808262 | 0.87 | CDK4 (0.49) | CDK4CCND1CCND2CCND3CYP1A2 | |
| SCHEMBL6807957 | 0.86 | CDK4 (0.65) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL5265151 | 0.86 | CDK4 (0.69) | CDK4CCND1CCND2CCND3CYP1A2 | |
| SCHEMBL5267894 | 0.82 | CDK4 (0.75) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL5266416 | 0.80 | CDK4 (0.47) | CDK4CCND1CCND2CCND3CYP1A2 | |
| SCHEMBL5265487 | 0.80 | CDK4 (0.53) | CDK4CCND1CCND2CCND3FGFR1 | |
| SCHEMBL5264006 | 0.79 | CDK4 (0.67) | CDK4CCND1CCND2CCND3CYP1A2 | |
| SCHEMBL5265241 | 0.79 | CDK4 (0.74) | CDK4CCND1CCND2CCND3FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040224958-A1 | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease | BOOTH RICHARD JOHN (US) | 2004-11-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040224958-A1 | Pyridopyrimidinone derivatives for treatment of neurodegenerative disease | CDK4, CDKL1, CCNT1 | CDK4 1/4885CCND1 23/4885CCND2 25/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.