SCHEMBL6803466

SCHEMBL6803466

COc1ccc(CCNC(=O)/C(=C/OC(F)F)c2ccc3c(c2)CCCC3)cc1OC

nearest known ligand 0.49

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.49
MAPT P10636 2/20 0.49
THRB P10828 2/20 0.49
ALDH1A1 P00352 8/20 0.48
POLB P06746 1/20 0.47
SMN1; SMN2 Q16637 2/20 0.46
HTT P42858 1/20 0.46
NPSR1 Q6W5P4 1/20 0.46
GAA P10253 2/20 0.46
CA12 O43570 1/20 0.45
CA1 P00915 1/20 0.45
CA2 P00918 1/20 0.45
CA9 Q16790 1/20 0.45
HPGD P15428 1/20 0.45
MEN1 O00255 1/20 0.44
PKM P14618 1/20 0.44
KMT2A Q03164 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6797833 1.00 LMNA (0.49) LMNAMAPTTHRBALDH1A1POLB
SCHEMBL6807160 0.99 LMNA (0.49) LMNAMAPTTHRBALDH1A1POLB
SCHEMBL6807163 0.99 LMNA (0.49) LMNAMAPTTHRBALDH1A1POLB
SCHEMBL6798927 0.94 LMNA (0.44) LMNAMAPTTHRBALDH1A1POLB
SCHEMBL6802311 0.94 MAPT (0.48) LMNAMAPTTHRBALDH1A1POLB
SCHEMBL6802313 0.94 MAPT (0.48) LMNAMAPTTHRBALDH1A1POLB
SCHEMBL6798923 0.94 LMNA (0.44) LMNAMAPTTHRBALDH1A1POLB
SCHEMBL6801331 0.94 MAPT (0.48) LMNAMAPTTHRBALDH1A1POLB
SCHEMBL6807104 0.94 MAPT (0.44) LMNAMAPTTHRBALDH1A1POLB
SCHEMBL6802300 0.93 MAPT (0.44) LMNAMAPTTHRBALDH1A1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6762321-B2 SUCH AS N-(2-(3,4-DIMETHOXYPHENYL)ETHYL)-3-DIFLUOROMETHOXY-2-(4 -METHYLPHENYL)ACRYLAMIDE; FUNGICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2004-07-13 US disclosed
US-20030195354-A1 Amide compounds and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-10-16 US disclosed
EP-1295868-A1 AMIDE COMPOUNDS AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2003-03-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030195354-A1 Amide compounds and use thereof CBR1, CBR3, NAT1 LMNA 3535/4885MAPT 3676/4885THRB 3020/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.