Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | RXRG | P48443 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 5/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680373 | 0.88 | EGFR (0.40) | RXRARXRBRXRGEGFRALDH1A1 | |
| SCHEMBL680121 | 0.86 | RXRA (0.41) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL5413224 | 0.77 | RXRA (0.54) | RXRARXRBRXRGPOLBALDH1A1 | |
| SCHEMBL2144070 | 0.77 | RXRA (0.47) | RXRARXRBRXRGPOLBALDH1A1 | |
| SCHEMBL29741242 | 0.77 | RXRA (0.47) | RXRARXRBRXRGPOLBALDH1A1 | |
| SCHEMBL680498 | 0.75 | EGFR (0.37) | RXRARXRBRXRGMEN1KMT2A | |
| SCHEMBL679462 | 0.74 | RXRA (0.39) | RXRARXRBRXRGPOLBEGFR | |
| SCHEMBL680051 | 0.73 | RXRA (0.42) | RXRARXRBRXRGKMT2APOLB | |
| SCHEMBL679190 | 0.72 | RXRA (0.43) | RXRARXRBRXRGEGFRALDH1A1 | |
| SCHEMBL679898 | 0.72 | RXRA (0.38) | RXRARXRBRXRGKMT2AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |