Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TNF | P01375 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL784573 | 0.83 | HTT (1.00) | HTTTDP1EGLN3LTA4HLMNA | |
| SCHEMBL13186931 | 0.81 | HTT (0.77) | HTTTDP1EGLN3LTA4HLMNA | |
| SCHEMBL11313566 | 0.81 | HTT (0.77) | HTTTDP1EGLN3LTA4HLMNA | |
| SCHEMBL16147345 | 0.81 | HTT (0.77) | HTTTDP1EGLN3LTA4HLMNA | |
| Hydrochloric Acid SCHEMBL30341872 | 0.79 | HTT (0.74) | HTTTDP1EGLN3LTA4HLMNA | |
| Hydrochloric Acid SCHEMBL29006871 | 0.79 | HTT (0.74) | HTTTDP1EGLN3LTA4HLMNA | |
| SCHEMBL30581441 | 0.78 | HTT (0.67) | HTTTDP1EGLN3LMNASMN1; SMN2 | |
| SCHEMBL7259109 | 0.78 | HTT (0.77) | HTTTDP1EGLN3LTA4HLMNA | |
| SCHEMBL24041763 | 0.77 | HTT (0.70) | HTTTDP1LTA4HLMNASMN1; SMN2 | |
| SCHEMBL24041750 | 0.76 | L3MBTL1 (0.74) | HTTTDP1LTA4HLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6770647-B2 | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-08-03 | — | — | US | disclosed |