Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 6/20 | 0.70 |
| ▸ | CTSV | O60911 | 4/20 | 0.70 |
| ▸ | CTSL | P07711 | 4/20 | 0.70 |
| ▸ | CTSK | P43235 | 4/20 | 0.52 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.45 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.45 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.45 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.45 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.45 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.45 |
| ▸ | CCR1 | P32246 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.39 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6798026 | 0.99 | CTSS (0.68) | CTSSCTSVCTSLCTSKPSEN1 | |
| SCHEMBL6808702 | 0.95 | CTSS (0.77) | CTSSCTSVCTSLCTSKPSEN1 | |
| SCHEMBL13677209 | 0.95 | CTSS (0.77) | CTSSCTSVCTSLCTSKPSEN1 | |
| SCHEMBL4451481 | 0.95 | CTSS (0.77) | CTSSCTSVCTSLCTSKPSEN1 | |
| SCHEMBL6803217 | 0.94 | CTSS (0.75) | CTSSCTSVCTSLCTSKPSEN1 | |
| SCHEMBL6803915 | 0.91 | CTSS (0.68) | CTSSCTSVCTSLCTSKCCR1 | |
| SCHEMBL6804753 | 0.90 | CTSS (0.66) | CTSSCTSVCTSLCTSKCCR1 | |
| SCHEMBL6798845 | 0.89 | CTSS (0.56) | CTSSCTSVCTSLCTSKCCR1 | |
| SCHEMBL4451187 | 0.87 | CTSS (0.91) | CTSSCTSVCTSLCTSKCTSB | |
| SCHEMBL13677398 | 0.87 | CTSS (0.91) | CTSSCTSVCTSLCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138250-A1 | Inhibitors of cruzipain and other cysteine proteases | GRUNENTHAL GMBH (DE) | 2004-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138250-A1 | Inhibitors of cruzipain and other cysteine proteases | CPN1, CTRL, CPA1 | CTSS 39/4885CTSV 27/4885CTSL 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.