Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6363842 | 0.79 | GRIN2B (0.45) | GRIN2BALDH1A1GAACOMTS1PR1 | |
| SCHEMBL6355947 | 0.78 | GRIN2B (0.41) | GRIN2BMAPK1ALDH1A1TDP1LMNA | |
| SCHEMBL6363840 | 0.76 | GRIN2B (0.45) | GRIN2BALDH1A1GAACOMTS1PR1 | |
| SCHEMBL20831282 | 0.73 | MAPK1 (0.41) | GRIN2BMAPK1ALDH1A1TDP1LMNA | |
| SCHEMBL6796312 | 0.72 | GRIN2B (0.42) | GRIN2BALDH1A1GAACOMTMAPT | |
| SCHEMBL860416 | 0.70 | GRIN2B (0.38) | GRIN2BLMNACOMTS1PR1S1PR5 | |
| SCHEMBL2598867 | 0.70 | GRIN2B (0.38) | GRIN2BLMNACOMTS1PR1S1PR5 | |
| SCHEMBL861683 | 0.70 | GRIN2B (0.38) | GRIN2BLMNACOMTS1PR1S1PR5 | |
| SCHEMBL2598868 | 0.70 | GRIN2B (0.38) | GRIN2BLMNACOMTS1PR1S1PR5 | |
| SCHEMBL6796136 | 0.70 | GRIN2B (0.58) | GRIN2BMAPK1ALDH1A1TDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6821964-B2 | FOR PROPHYLAXIS AND THERAPY OF DISEASES ASSOCIATED WITH MONOCYTE ACCUMULATION, LYMPHOCYTE ACCUMULATION OR LEUCOCYTE ACCUMULATION | PFIZER INC | 2004-11-23 | — | — | US | disclosed |