Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CASP7 | P55210 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TYMS | P04818 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11997405 | 0.76 | MAPT (0.37) | KDM4EMAPTALDH1A1CASP1NPC1 | |
| SCHEMBL656011 | 0.76 | CASP1 (0.55) | MAPTALDH1A1CASP1NPC1LMNA | |
| SCHEMBL30067461 | 0.76 | CASP1 (0.55) | MAPTALDH1A1CASP1NPC1LMNA | |
| SCHEMBL14409505 | 0.76 | HPGD (0.53) | KDM4EMAPTALDH1A1CASP1NPC1 | |
| SCHEMBL42805 | 0.73 | CA12 (0.48) | KDM4EMAPTALDH1A1CASP1NPC1 | |
| SCHEMBL29779691 | 0.73 | CA12 (0.48) | KDM4EMAPTALDH1A1CASP1NPC1 | |
| SCHEMBL4878376 | 0.72 | CASP1 (0.55) | MAPTALDH1A1CASP1NPC1LMNA | |
| SCHEMBL6797539 | 0.72 | KDM4E (0.48) | KDM4EMAPTALDH1A1NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL2476978 | 0.72 | CA12 (0.47) | KDM4EMAPTALDH1A1CASP1NPC1 | |
| SCHEMBL7471741 | 0.71 | CASP1 (0.59) | PDE10AKDM4EMAPTALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6750243-B1 | COMPETITIVE INHIBITORS OF TRYPSIN-LIKE SERINE PROTEASES, ESPECIALLY THROMBIN; chemical synthesis; anticoagulants; treatment of thrombosis | AstraZeneća AB (SE) | 2004-06-15 | — | — | US | claimed |