Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 13/20 | 0.56 |
| ▸ | MET | P08581 | 10/20 | 0.54 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.54 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.54 |
| ▸ | MERTK | Q12866 | 4/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680684 | 1.00 | AXL (0.56) | AXLMETRIPK3TYRO3MERTK | |
| SCHEMBL681013 | 0.92 | AXL (0.53) | AXLMETRIPK3TYRO3MERTK | |
| SCHEMBL681026 | 0.92 | AXL (0.53) | AXLMETRIPK3TYRO3MERTK | |
| SCHEMBL14326426 | 0.91 | AXL (0.52) | AXLMETRIPK3TYRO3MERTK | |
| SCHEMBL680709 | 0.89 | AXL (0.58) | AXLMETRIPK3TYRO3MERTK | |
| SCHEMBL680268 | 0.87 | AXL (0.55) | AXLMETRIPK3TYRO3MERTK | |
| SCHEMBL681063 | 0.86 | AXL (0.54) | AXLMETRIPK3TYRO3MERTK | |
| SCHEMBL681138 | 0.84 | AXL (0.61) | AXLMETRIPK3TYRO3MERTK | |
| SCHEMBL2492894 | 0.84 | MET (0.64) | AXLMETRIPK3TYRO3MERTK | |
| SCHEMBL679512 | 0.81 | AXL (0.55) | AXLMETTYRO3MERTKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |