Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | RXRG | P48443 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | HSPB1 | P04792 | 3/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680196 | 0.90 | SCN9A (0.39) | RXRARXRBRXRGL3MBTL1ALDH1A1 | |
| SCHEMBL679314 | 0.86 | RXRA (0.38) | RXRARXRBRXRGL3MBTL1ALDH1A1 | |
| SCHEMBL680923 | 0.86 | CYP11B1 (0.40) | RXRARXRBRXRGL3MBTL1ALDH1A1 | |
| SCHEMBL679898 | 0.86 | RXRA (0.38) | RXRARXRBRXRGL3MBTL1ALDH1A1 | |
| SCHEMBL679359 | 0.85 | RXRA (0.41) | RXRARXRBRXRGL3MBTL1ALDH1A1 | |
| SCHEMBL679358 | 0.85 | RXRA (0.41) | RXRARXRBRXRGL3MBTL1ALDH1A1 | |
| SCHEMBL680965 | 0.85 | RXRA (0.40) | RXRARXRBRXRGL3MBTL1ALDH1A1 | |
| SCHEMBL680305 | 0.85 | PLK4 (0.39) | RXRARXRBRXRGL3MBTL1ALDH1A1 | |
| SCHEMBL679190 | 0.84 | RXRA (0.43) | RXRARXRBRXRGL3MBTL1ALDH1A1 | |
| SCHEMBL680423 | 0.84 | EGFR (0.39) | RXRARXRBRXRGMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |