Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C2 | P52895 | 5/20 | 1.00 |
| ▸ | AKR1C1 | Q04828 | 5/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 3/20 | 1.00 |
| ▸ | PTPN1 | P18031 | 6/20 | 0.69 |
| ▸ | PTPN6 | P29350 | 3/20 | 0.63 |
| ▸ | PTPN2 | P17706 | 2/20 | 0.63 |
| ▸ | HNF4A | P41235 | 3/20 | 0.58 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.57 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.49 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5988766 | 0.82 | AKR1C3 (0.69) | AKR1C2AKR1C1AKR1C3PTPN1PTPN6 | |
| SCHEMBL9423180 | 0.82 | AKR1C3 (0.70) | AKR1C2AKR1C1AKR1C3PTPN1PTPN6 | |
| SCHEMBL5437754 | 0.81 | PTPN1 (1.00) | AKR1C2AKR1C1AKR1C3PTPN1PTPN6 | |
| SCHEMBL9245932 | 0.81 | PTPN1 (0.73) | AKR1C2AKR1C1AKR1C3PTPN1PTPN6 | |
| SCHEMBL30763496 | 0.80 | PTPN1 (0.71) | AKR1C2AKR1C1AKR1C3PTPN1PTPN6 | |
| SCHEMBL10479912 | 0.80 | PTPN1 (0.71) | AKR1C2AKR1C1AKR1C3PTPN1PTPN6 | |
| SCHEMBL9769768 | 0.80 | PTPN1 (0.71) | AKR1C2AKR1C1AKR1C3PTPN1PTPN6 | |
| SCHEMBL6842109 | 0.79 | PTPN1 (0.70) | AKR1C2AKR1C1AKR1C3PTPN1PTPN6 | |
| SCHEMBL28680647 | 0.79 | AKR1C3 (0.64) | AKR1C2AKR1C1AKR1C3PTPN1PTPN6 | |
| SCHEMBL9651394 | 0.79 | PTPN1 (0.69) | AKR1C2AKR1C1AKR1C3PTPN1PTPN6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6831190-B1 | Acts effectively in stomach, the antibacterial activity becomes weak as the compounds moves from duodenum to small intestines; do not have activity against esylhiacori, staphylococcus aureus, methacycline resistant bacterium | TEIKOKU CHEMICAL INDUSTRIES CO., LTD. (JP) | 2004-12-14 | — | — | US | disclosed |
| EP-1449828-A2 | Guanidinomethyl cyclohexane carboxylic acid ester derivatives | Nagase ChemteX Corporation (JP) | 2004-08-25 | — | — | EP | disclosed |
| EP-0989112-B1 | Intermediates for the preparation of guanidinomethyl cyclohexane carboxylic acid ester derivatives | NAGASE CHEMTEX CORP (JP) | 2004-04-14 | — | — | EP | disclosed |
| US-6284791-B1 | USEFUL AS AN ANTI-MICROBIAL AGAINST HELICOBACTER PYLORI | TEIKOKU CHEMICAL INDUSTRIES CO., LTD. (JP) | 2001-09-04 | — | — | US | disclosed |
| EP-0775692-B1 | GUANIDINOMETHYL CYCLOHEXANE CARBOXYLIC ESTER DERIVATIVE | TEIKOKU CHEM IND CO LTD (JP) | 2000-12-06 | — | — | EP | disclosed |
| EP-0989112-A2 | Intermediates for the preparation of guanidinomethyl cyclohexane carboxylic acid ester derivatives | TEIKOKU CHEMICAL INDUSTRY CO., LTD. (JP) | 2000-03-29 | — | — | EP | disclosed |
| EP-0775692-A1 | GUANIDINOMETHYL CYCLOHEXANE CARBOXYLIC ESTER DERIVATIVE | TEIKOKU CHEMICAL INDUSTRY CO., LTD. (JP) | 1997-05-28 | — | — | EP | disclosed |