Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | TEC | P42680 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680070 | 0.83 | ALDH1A1 (0.45) | ROCK2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL680323 | 0.78 | TLR8 (0.44) | ROCK2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL679260 | 0.77 | TLR8 (0.59) | ROCK2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL680227 | 0.77 | KDM4E (0.46) | ROCK2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL8325182 | 0.76 | KDM4E (0.58) | ROCK2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL2876364 | 0.76 | ROCK1 (0.58) | ROCK2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL680692 | 0.76 | TLR8 (0.41) | ROCK2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL680202 | 0.76 | TLR8 (0.46) | ROCK2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL680260 | 0.75 | TLR8 (0.46) | ROCK2KDM4EMEN1MAPTKMT2A | |
| SCHEMBL680251 | 0.74 | FGFR1 (0.45) | ROCK2KDM4EMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |