Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.49 |
| ▸ | MMP1 | P03956 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7467309 | 0.97 | TSHR (0.52) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL9263357 | 0.89 | KMT2A (0.60) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL9077833 | 0.84 | HSD17B3 (0.66) | ALDH1A1L3MBTL1HDAC8HDAC1TSHR | |
| SCHEMBL9077880 | 0.84 | KMT2A (0.55) | MAPTMEN1KMT2AHDAC8HDAC1 | |
| SCHEMBL10950721 | 0.83 | KMT2A (0.54) | MAPTMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL25456558 | 0.83 | KMT2A (0.53) | MAPTMEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL11603233 | 0.83 | HDAC8 (0.53) | MAPTALDH1A1LMNAL3MBTL1HDAC8 | |
| SCHEMBL6814347 | 0.83 | NPC1 (0.67) | MEN1KMT2AALDH1A1LMNAL3MBTL1 | |
| SCHEMBL7243792 | 0.83 | HDAC1 (0.63) | MAPTMEN1KMT2AALDH1A1L3MBTL1 | |
| SCHEMBL10706454 | 0.83 | SLC6A4 (0.54) | MAPTMEN1KMT2AALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040138287-A1 | Novel 5-phenyl-1h-indole derivatives as antagonists of interleukine-8 receptors | LABORATOIRES FOURNIER S.A. (FR) | 2004-07-15 | — | — | US | disclosed |
| US-6605633-B1 | Such as 5-Bromo-2-phenyl-1H-indole-3-butanoic acid | FOURNIER INDUSTRIE ET SANTE (FR) | 2003-08-12 | — | — | US | disclosed |
| US-6498179-B1 | SUCH AS 4-(4-CHLOROPHENYL)-5-(3-(2-METHOXYPHENOXY)PROPYL)-2-(2-METHYL-1 -IMIDAZOLYL)OXAZOLE; INSULIN SECERTION PROMOTING AND BLOOD SUGAR DEPRESSING EFFECT; DIABETES; LOW TOXICITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2002-12-24 | — | — | US | disclosed |
| EP-0891340-B1 | OXAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | disclosed |
| US-6177452-B1 | ANTIDIABETIC AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-01-23 | — | — | US | disclosed |
| EP-0891340-A1 | OXAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | Takeda Chemical Industries, Ltd. (JP) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036882-A1 | OXAZOLE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138287-A1 | Novel 5-phenyl-1h-indole derivatives as antagonists of interleukine-8 receptors | CXCL8, IL1RN, CCR8 | MAPT 2799/4885MEN1 4703/4885KMT2A 4030/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.