Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CBFB | Q13951 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 6/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TACR3 | P29371 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1536729 | 0.83 | CYP3A4 (0.51) | ALDH1A1KDM4ESMN1; SMN2TLR8NPC1 | |
| SCHEMBL12732312 | 0.81 | KDM4E (0.58) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL8139843 | 0.80 | ACP1 (0.43) | ALDH1A1KDM4ESMN1; SMN2TLR8EGFR | |
| SCHEMBL2214881 | 0.80 | POLB (0.47) | ALDH1A1KDM4ESMN1; SMN2TLR8NPC1 | |
| SCHEMBL7395996 | 0.79 | SMN1; SMN2 (0.44) | ALDH1A1KDM4ESMN1; SMN2TLR8NPC1 | |
| SCHEMBL743975 | 0.78 | KDM4E (0.72) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A | |
| SCHEMBL6809754 | 0.78 | KDM4E (0.46) | ALDH1A1KDM4ESMN1; SMN2TLR8NPC1 | |
| SCHEMBL8161422 | 0.77 | RAC1 (0.52) | ALDH1A1KDM4ESMN1; SMN2TLR8NPC1 | |
| SCHEMBL8138975 | 0.77 | KDM4E (0.42) | ALDH1A1KDM4ESMN1; SMN2TLR8MPO | |
| SCHEMBL7396057 | 0.77 | SMN1; SMN2 (0.45) | ALDH1A1KDM4ESMN1; SMN2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1169339-B1 | MACROCYCLIC PEPTIDES INHIBITING THE HEPATITIS C VIRUS NS3 PROTEASE | BOEHRINGER INGELHEIM CA LTD (CA) | 2004-09-29 | — | — | EP | disclosed |
| EP-1437362-A1 | Macrocyclic peptides inhibiting the hepatitis C virus ns3 protease | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2004-07-14 | — | — | EP | disclosed |
| US-20040002448-A1 | Macrocyclic peptides active against the hepatitis C virus | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2004-01-01 | — | — | US | disclosed |
| US-6608027-B1 | Macrocyclic small peptides of low molecular weight that are inhibitory to NS3 protease of hepatitis C virus | BOEHRINGER INGELHEIM (CANADA) LTD (CA) | 2003-08-19 | — | — | US | disclosed |
| EP-1169339-A1 | MACROCYCLIC PEPTIDES INHIBITING THE HEPATITIS C VIRUS NS3 PROTEASE | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2002-01-09 | — | — | EP | disclosed |
| WO-2000059929-A1 | MACROCYCLIC PEPTIDES ACTIVE AGAINST THE HEPATITIS C VIRUS | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2000-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040002448-A1 | Macrocyclic peptides active against the hepatitis C virus | VIP, FURIN, RNASE1 | ALDH1A1 1770/4885KDM4E 3584/4885SMN1; SMN2 2976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.