Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 3/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.51 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.51 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | PRKCG | P05129 | 1/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.51 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.51 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6799887 | 0.91 | KDM4E (0.44) | GSK3APIM1DYRK1APIM3AURKB | |
| SCHEMBL6809666 | 0.85 | PIM1 (0.70) | GSK3APIM1DYRK1APIM3AURKB | |
| SCHEMBL6806642 | 0.82 | PIM1 (0.73) | GSK3APIM1DYRK1APIM3AURKB | |
| SCHEMBL6805777 | 0.82 | PRKD3 (0.53) | GSK3APIM1DYRK1APIM3AURKB | |
| SCHEMBL6807423 | 0.82 | PIM1 (0.45) | GSK3APIM1DYRK1APIM3AURKB | |
| SCHEMBL6811032 | 0.81 | PIM1 (0.45) | GSK3APIM1DYRK1APIM3AURKB | |
| SCHEMBL6799726 | 0.81 | GSK3A (0.52) | GSK3APIM1DYRK1APIM3AURKB | |
| SCHEMBL6805548 | 0.81 | PIM1 (0.45) | GSK3APIM1DYRK1APIM3AURKB | |
| SCHEMBL6803660 | 0.80 | PIM1 (0.46) | GSK3APIM1DYRK1APIM3AURKB | |
| SCHEMBL6805712 | 0.80 | PIM1 (0.47) | GSK3APIM1DYRK1APIM3AURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |