Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.54 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 12/20 | 0.45 |
| ▸ | CNR2 | P34972 | 3/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6806391 | 1.00 | AURKA (0.54) | AURKAAURKBKDRPARP1CNR2 | |
| SCHEMBL6805914 | 0.99 | AURKA (0.55) | AURKAAURKBKDRPARP1CNR2 | |
| SCHEMBL6812407 | 0.91 | AURKA (0.50) | AURKAAURKBKDRPARP1DGAT1 | |
| SCHEMBL6805728 | 0.91 | AURKA (0.53) | AURKAAURKBKDRPARP1DGAT1 | |
| SCHEMBL6810130 | 0.90 | AURKA (0.54) | AURKAAURKBKDRPARP1DGAT1 | |
| SCHEMBL6806130 | 0.90 | AURKA (0.56) | AURKAAURKBKDRPARP1DGAT1 | |
| SCHEMBL6806351 | 0.90 | AURKA (0.59) | AURKAAURKBKDRPARP1DGAT1 | |
| SCHEMBL6802984 | 0.90 | JAK2 (0.53) | AURKAAURKBKDRPARP1CNR2 | |
| SCHEMBL6805042 | 0.89 | AURKA (0.57) | AURKAAURKBKDRPARP1DGAT1 | |
| SCHEMBL6812191 | 0.88 | AURKA (0.51) | AURKAAURKBKDRPARP1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6696437-B1 | Heterocyclically substituted benzimidazoles, the production and application thereof | ABBOTT GMBH & CO. KG (DE) | 2004-02-24 | — | — | US | disclosed |