Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.66 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.66 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.66 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.66 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.66 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ITGB1 | P05556 | 8/20 | 0.50 |
| ▸ | ITGA4 | P13612 | 8/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12203729 | 0.84 | PSEN1 (0.91) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7240425 | 0.81 | ITGB1 (0.50) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL5249658 | 0.79 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3904073 | 0.78 | ITGB1 (0.67) | ALDH1A1HTTITGB1ITGA4ITGB7 | |
| SCHEMBL3904078 | 0.78 | ITGB1 (0.67) | ALDH1A1HTTITGB1ITGA4ITGB7 | |
| SCHEMBL6367506 | 0.78 | ITGB1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7450743 | 0.78 | ITGB1 (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3901904 | 0.77 | ITGB1 (0.59) | ITGB1ITGA4ITGB7 | |
| SCHEMBL29575786 | 0.77 | ITGB1 (0.65) | ITGB1ITGA4ITGB7 | |
| SCHEMBL16169932 | 0.77 | PSEN1 (0.60) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040132809-A1 | Cell adhesion inhibitors | BIOGEN, INC. | 2004-07-08 | — | — | US | claimed |
| US-6630503-B1 | Non-peptidic sulfonamide compounds that specifically inhibit the binding of ligands to VLA-4 for inhibition, prevention and suppression of VLA-4-mediated cell adhesion and pathologies such as inflammation and immune reactions | BIOGEN, INC. | 2003-10-07 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040132809-A1 | Cell adhesion inhibitors | VCAM1, ICAM1, EPCAM | PSEN1 1815/4885PSEN2 2895/4885APH1B 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.