Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 7/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 4/20 | 0.34 |
| ▸ | MERTK | Q12866 | 2/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | MST1R | Q04912 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.34 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.34 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679511 | 0.83 | AXL (0.55) | KDRAXLMETMERTKTYRO3 | |
| SCHEMBL679512 | 0.83 | AXL (0.55) | KDRAXLMETMERTKTYRO3 | |
| SCHEMBL681013 | 0.82 | AXL (0.53) | KDRAXLMETMERTKTYRO3 | |
| SCHEMBL681026 | 0.82 | AXL (0.53) | KDRAXLMETMERTKTYRO3 | |
| SCHEMBL13541753 | 0.78 | BRAF (0.37) | KDRBRAFAKT1KIF18AROCK1 | |
| SCHEMBL680685 | 0.74 | AXL (0.56) | KDRAXLMETMERTKTYRO3 | |
| SCHEMBL680684 | 0.74 | AXL (0.56) | KDRAXLMETMERTKTYRO3 | |
| SCHEMBL680780 | 0.73 | AXL (0.64) | KDRAXLMETMERTKTYRO3 | |
| SCHEMBL680526 | 0.72 | AXL (0.57) | AXLMETMERTKTYRO3 | |
| SCHEMBL12190687 | 0.72 | AXL (0.51) | AXLMETMERTKTYRO3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |