Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 11/20 | 0.56 |
| ▸ | DRD2 | P14416 | 9/20 | 0.56 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | HTR7 | P34969 | 3/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.52 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.52 |
| ▸ | HTR3B | O95264 | 1/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | PGR | P06401 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | GOT1 | P17174 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6810781 | 0.88 | HTR2A (0.59) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL6810694 | 0.88 | HTR2A (0.60) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL6810948 | 0.86 | HTR2A (0.59) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL6184604 | 0.85 | HTR2A (0.58) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL6185743 | 0.84 | HTR2A (0.56) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL6748876 | 0.83 | HTR1A (0.58) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL6816358 | 0.83 | HTR2A (0.56) | HTR2ADRD2HTR1AHTR7HTR6 | |
| SCHEMBL6807605 | 0.81 | HTR2A (0.60) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL6810708 | 0.79 | HTR2A (0.57) | HTR2ADRD2HTR1AHTR7KCNH2 | |
| SCHEMBL6185507 | 0.79 | HTR2A (0.58) | HTR2ADRD2HTR1AHTR7KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040067960-A1 | Heterocyclic substituted piperazines for the treatment of schizophrenia | DAVIS JAMIE MARIE (US) | 2004-04-08 | — | — | US | claimed |
| US-20040067960-A1 | Heterocyclic substituted piperazines for the treatment of schizophrenia | DAVIS JAMIE MARIE (US) | 2004-04-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040067960-A1 | Heterocyclic substituted piperazines for the treatment of schizophrenia | HTR2C, CNR1, HTR2A | HTR2A 3/4885DRD2 4/4885HTR1A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.