Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.53 |
| ▸ | MMP13 | P45452 | 19/20 | 0.53 |
| ▸ | MMP9 | P14780 | 18/20 | 0.53 |
| ▸ | MMP1 | P03956 | 12/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3945004 | 0.88 | ADAM17 (0.68) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL3938974 | 0.87 | ADAM17 (0.67) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6816319 | 0.85 | ADAM17 (0.68) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6814832 | 0.84 | ADAM17 (0.69) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6820054 | 0.83 | ADAM17 (0.70) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL3945507 | 0.82 | ADAM17 (0.76) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL3942775 | 0.82 | ADAM17 (0.58) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6819078 | 0.82 | ADAM17 (0.65) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6813866 | 0.81 | ADAM17 (0.58) | ADAM17MMP13MMP9MMP1 | |
| SCHEMBL6820235 | 0.80 | ADAM17 (0.73) | ADAM17MMP13MMP9MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144369-B1 | ACETYLENIC ARYL SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | claimed |