Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 8/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 7/20 | 0.40 |
| ▸ | ADRB3 | P13945 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL681754 | 0.90 | ADRB2 (0.35) | ADRB2ADRB1ADRB3TSHRHIF1A | |
| SCHEMBL680060 | 0.84 | ADRB2 (0.44) | ADRB2ADRB1ADRB3TSHRHIF1A | |
| SCHEMBL681274 | 0.84 | ADRB2 (0.40) | ADRB2ADRB1ADRB3TSHRHIF1A | |
| SCHEMBL684339 | 0.82 | ADRB2 (0.41) | ADRB2ADRB1ADRB3TSHRHIF1A | |
| SCHEMBL680064 | 0.80 | PDPK1 (0.44) | ADRB2ADRB1ADRB3TSHRHIF1A | |
| SCHEMBL681163 | 0.80 | TACR1 (0.37) | ADRB2ADRB1ADRB3TSHRHIF1A | |
| SCHEMBL17803796 | 0.78 | ADRB2 (0.41) | ADRB2ADRB1ADRB3TSHRHIF1A | |
| SCHEMBL17803797 | 0.78 | ADRB2 (0.38) | ADRB2ADRB1ADRB3TSHRHIF1A | |
| SCHEMBL681539 | 0.77 | AKT1 (0.44) | ADRB2ADRB1ADRB3TSHRHIF1A | |
| SCHEMBL680197 | 0.77 | ADRB2 (0.40) | ADRB2ADRB1ADRB3TSHRHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |