Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
| ▸ | MCHR1 | Q99705 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | FOXM1 | Q08050 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | AKT2 | P31751 | 1/20 | 0.38 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680237 | 0.88 | MEN1 (0.48) | MEN1KMT2AMITFMCHR1SMN1; SMN2 | |
| SCHEMBL680840 | 0.88 | MEN1 (0.50) | MEN1KMT2AMITFMCHR1POLB | |
| SCHEMBL680141 | 0.87 | AKT3 (0.45) | MCHR1POLBSMN1; SMN2EPHX1GAA | |
| SCHEMBL12188421 | 0.85 | MCHR1 (0.50) | MEN1KMT2AMITFMCHR1POLB | |
| SCHEMBL10257139 | 0.82 | MCHR1 (0.50) | MEN1KMT2AMITFMCHR1POLB | |
| SCHEMBL681566 | 0.80 | MEN1 (0.40) | MEN1KMT2AMITFPOLBSMN1; SMN2 | |
| SCHEMBL17803819 | 0.80 | KDM4E (0.42) | MEN1KMT2APOLBSMN1; SMN2GAA | |
| SCHEMBL681002 | 0.77 | AKT3 (0.47) | MCHR1POLBSMN1; SMN2EPHX1GAA | |
| SCHEMBL680114 | 0.76 | BRD4 (0.42) | MEN1KMT2AMITFSMN1; SMN2GAA | |
| SCHEMBL679786 | 0.76 | MEN1 (0.48) | MEN1KMT2AMITFMCHR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |