Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PTH1R | Q03431 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL679786 | 0.88 | MEN1 (0.48) | MEN1KMT2AMITFAKT1AKT2 | |
| SCHEMBL681303 | 0.88 | MEN1 (0.36) | MEN1KMT2AMITFOPRL1 | |
| SCHEMBL681244 | 0.88 | MEN1 (0.50) | MEN1KMT2AMITFAKT1AKT2 | |
| SCHEMBL681300 | 0.88 | AKT3 (0.47) | MEN1KMT2AMITFAKT1AKT2 | |
| SCHEMBL12188441 | 0.85 | MEN1 (0.47) | MEN1KMT2AMITFAKT1AKT2 | |
| SCHEMBL10263300 | 0.83 | MEN1 (0.44) | MEN1KMT2AMITFAKT1AKT2 | |
| SCHEMBL681761 | 0.81 | AKT3 (0.41) | MEN1KMT2AMITFAKT1AKT2 | |
| SCHEMBL681164 | 0.81 | AKT3 (0.41) | MEN1KMT2AMITFAKT1AKT2 | |
| SCHEMBL681566 | 0.78 | MEN1 (0.40) | MEN1KMT2AMITFAKT1AKT2 | |
| SCHEMBL679641 | 0.78 | AKT3 (0.49) | MEN1KMT2AMITFAKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9359340-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as Akt protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2016-06-07 | — | — | US | disclosed |
| US-8063050-B2 | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2011-11-22 | — | — | US | disclosed |