Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 19/20 | 0.82 |
| ▸ | PLA2G1B | P04054 | 7/20 | 0.82 |
| ▸ | PLA2G10 | O15496 | 6/20 | 0.82 |
| ▸ | PLA2G2E | Q9NZK7 | 6/20 | 0.82 |
| ▸ | PLA2G5 | P39877 | 5/20 | 0.82 |
| ▸ | PLA2G2F | Q9BZM2 | 4/20 | 0.82 |
| ▸ | PLA2G2D | Q9UNK4 | 4/20 | 0.82 |
| ▸ | PLA2G6 | O60733 | 1/20 | 0.82 |
| ▸ | PLA2G2C | Q5R387 | 1/20 | 0.82 |
| ▸ | PLA2G12B | Q9BX93 | 1/20 | 0.82 |
| ▸ | PLA2G12A | Q9BZM1 | 1/20 | 0.82 |
| ▸ | PLA2G3 | Q9NZ20 | 1/20 | 0.82 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Varespladib Methyl SCHEMBL29378302 | 0.91 | PLA2G2A (0.83) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| Varespladib Methyl SCHEMBL25678 | 0.91 | PLA2G2A (0.83) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| SCHEMBL4652248 | 0.90 | PLA2G2A (0.81) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| Varespladib SCHEMBL29358982 | 0.90 | PLA2G2A (1.00) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| Varespladib SCHEMBL26726 | 0.90 | PLA2G2A (1.00) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| SCHEMBL5710595 | 0.89 | PLA2G2A (0.82) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| SCHEMBL5710565 | 0.88 | PLA2G2A (0.80) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| Varespladib SCHEMBL1232548 | 0.87 | PLA2G2A (0.83) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| Varespladib SCHEMBL29430154 | 0.87 | PLA2G2A (0.83) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 | |
| SCHEMBL5710700 | 0.86 | PLA2G2A (0.82) | PLA2G2APLA2G1BPLA2G10PLA2G2EPLA2G5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1073440-B1 | sPLA 2 INHIBITOR ESTERS | LILLY CO ELI (US) | 2004-10-20 | — | — | EP | disclosed |
| US-6274578-B1 | ((3-(2-AMINO-1,2-DIOXOETHYL)-2-METHYL-1-(PHENYLMETHYL)-1H--IND OL-4-YL)OXY)ACETIC ACID N-MORPHOLINO ETHYL ESTER; RESPIRATORY SYSTEM DISORDERS | ELI LILLY AND COMPANY | 2001-08-14 | — | — | US | disclosed |
| US-6140327-A | FOR TREATOMG SEPTIC SHOCK, ADULT RESPIRATORY DISTRESS SYNDROME, PANCREATITIS, TRAUMA, BRONCHIAL ASTHMA, ALLERGIC RHINITIS, RHEUMATOID ARTHRITIS, STROKE, ACUTE BRONCHITIS, CHRONIC BRONCHITIS, ACUTE BRONCHIOLITIS, OSTEOARTHRITIS, GOUT | ELI LILLY AND COMPANY (US) | 2000-10-31 | — | — | US | disclosed |