Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817211 | 0.93 | CHRM2 (0.36) | CHRNB2CHRNA4CHRM2CHRM1CHRM4 | |
| SCHEMBL6816338 | 0.85 | CHRM2 (0.30) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL6813247 | 0.75 | CHRM2 (0.31) | CHRNB2CHRNA4CHRM2CHRM1CHRM4 | |
| SCHEMBL6817810 | 0.74 | TOP1 (0.30) | — | |
| SCHEMBL8935511 | 0.72 | CHRM2 (0.45) | CHRNB2CHRNA4CHRM2CHRM1CHRM4 | |
| SCHEMBL6816895 | 0.70 | — | — | |
| SCHEMBL6817171 | 0.69 | CHRNB2 (0.32) | CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6817751 | 0.68 | CHRNA7 (0.33) | CHRNA7 | |
| SCHEMBL8935498 | 0.67 | CHRM2 (0.54) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL7566718 | 0.67 | CHRNB2 (0.34) | CHRNB2CHRNA4CHRNB4CHRNA3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004009599-A1 | FIVE-MEMBERED HETEROAROMATIC OLEFINIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NCOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2004-01-29 | — | — | WO | claimed |
| WO-2004009599-A1 | FIVE-MEMBERED HETEROAROMATIC OLEFINIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NCOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2004-01-29 | — | — | WO | disclosed |