Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.57 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2295729 | 0.88 | MEN1 (0.66) | MEN1KMT2ANPC1RAB9AKCNK3 | |
| SCHEMBL17993344 | 0.88 | HDAC2 (0.61) | MEN1KMT2AKCNK3KCNK9POLB | |
| SCHEMBL14407440 | 0.88 | PTPN1 (0.58) | MEN1KMT2AKCNK3KCNK9POLB | |
| SCHEMBL677476 | 0.81 | MEN1 (0.67) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL22387581 | 0.80 | LMNA (0.67) | NPC1RAB9AKCNK3HDAC3 | |
| SCHEMBL13065988 | 0.79 | PTPN1 (0.66) | MEN1KMT2APOLBHDAC3HDAC1 | |
| SCHEMBL12540695 | 0.79 | MEN1 (0.67) | MEN1KMT2ANPC1RAB9APOLB | |
| SCHEMBL2911616 | 0.78 | HDAC2 (0.71) | MEN1KMT2ANPC1RAB9AKCNK3 | |
| SCHEMBL30643220 | 0.78 | MEN1 (0.88) | MEN1KMT2ANPC1RAB9AKCNK3 | |
| SCHEMBL1352405 | 0.78 | PTGS1 (0.68) | MEN1KMT2ANPC1RAB9AKCNK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1042276-B1 | THIOUREA COMPOUNDS, COMPOSITIONS AND METHODS OF TREATING OR PREVENTING INFLAMMATORY DISEASES AND ATHEROSCLEROSIS | WARNER LAMBERT CO (US) | 2004-11-17 | — | — | EP | disclosed |