Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 5/20 | 0.38 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.37 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.37 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1186123 | 0.88 | ALDH1A1 (0.50) | ALDH1A1TSHRKDM4ETDP1LMNA | |
| SCHEMBL3650254 | 0.87 | ALDH1A1 (0.46) | ALDH1A1TSHRKDM4ETDP1LMNA | |
| SCHEMBL7133759 | 0.87 | ALDH1A1 (0.48) | ALDH1A1TSHRKDM4ETDP1LMNA | |
| SCHEMBL7137814 | 0.85 | ALDH1A1 (0.47) | ALDH1A1TSHRKDM4ETDP1LMNA | |
| SCHEMBL7135494 | 0.85 | ALDH1A1 (0.47) | ALDH1A1TSHRKDM4ETDP1LMNA | |
| SCHEMBL4186655 | 0.83 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ETDP1LMNA | |
| SCHEMBL31738417 | 0.83 | ALDH1A1 (0.52) | ALDH1A1TSHRKDM4ETDP1LMNA | |
| SCHEMBL7137868 | 0.83 | ALDH1A1 (0.44) | ALDH1A1TSHRKDM4ETDP1TUBB1 | |
| SCHEMBL14242951 | 0.81 | ALDH1A1 (0.50) | ALDH1A1TSHRKDM4ETDP1LMNA | |
| SCHEMBL7616411 | 0.80 | ALDH1A1 (0.48) | ALDH1A1TSHRKDM4ETDP1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1114817-B1 | Substituted benzylamino piperidine compounds | PFIZER (US) | 2004-01-21 | — | — | EP | disclosed |
| US-6506775-B1 | Treatment of a gastrointestinal disorder; a central nervous system (CNS) adverse conditions caused by Heliobacter pylori; or angiogenesis especially CNS disorders in a mammalian subject, especially humans. | PFIZER INC | 2003-01-14 | — | — | US | disclosed |
| US-6329396-B1 | TREATMENT OF GASTROINTESTINAL DISORDERS CENTRAL NERVOUS SYSTEM (CNS) DISORDERS; INFLAMMATORY DISEASE; EMESIS; URINARY INCONTINENCE; PAIN; MIGRAINE; SUNBURN; DISEASES, DISORDERS AND ADVERSE CONDITIONS CAUSED BY HELIOBACTER PYLORI; OR | PFIZER INC. | 2001-12-11 | — | — | US | disclosed |
| EP-1114817-A1 | Substituted benzylamino piperidine compounds | PFIZER INC. (US) | 2001-07-11 | — | — | EP | disclosed |
| EP-0861235-A1 | SUBSTITUTED BENZYLAMINOPIPERIDINE COMPOUNDS | PFIZER INC. (US) | 1998-09-02 | — | — | EP | disclosed |
| WO-1997008144-A1 | SUBSTITUTED BENZYLAMINOPIPERIDINE COMPOUNDS | PFIZER PHARMACEUTICALS INC. (JP) | 1997-03-06 | — | — | WO | disclosed |