Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.59 |
| ▸ | RAB9A | P51151 | 9/20 | 0.59 |
| ▸ | POLB | P06746 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6814464 | 0.91 | KMT2A (0.61) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6819151 | 0.85 | NPC1 (0.59) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6864083 | 0.79 | NPC1 (0.50) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6855425 | 0.78 | POLB (0.54) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6815339 | 0.77 | POLB (0.77) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6813747 | 0.76 | KMT2A (0.61) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6814497 | 0.76 | POLB (0.75) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6862357 | 0.76 | POLB (0.48) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6811138 | 0.75 | AR (0.64) | NPC1RAB9APOLBKDM4ESMN1; SMN2 | |
| SCHEMBL6814481 | 0.75 | NPC1 (0.73) | NPC1RAB9APOLBKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004012656-A2 | THIOPHENE AND FURAN DERIVATIVES AS PROSTAGLANDIN AGONISTS AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-02-12 | — | — | WO | claimed |
| WO-2004012656-A2 | THIOPHENE AND FURAN DERIVATIVES AS PROSTAGLANDIN AGONISTS AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2004-02-12 | — | — | WO | disclosed |