Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL762108 | 0.81 | KDM4E (0.50) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL13917234 | 0.69 | KDM4E (0.50) | MEN1KMT2ACYP1A2CYP2C19ALDH1A1 | |
| SCHEMBL18704808 | 0.69 | KDM4E (0.50) | MEN1KMT2AMAPTTSHRHSD17B10 | |
| SCHEMBL17201206 | 0.69 | KDM4E (0.47) | MEN1KMT2ACYP1A2CYP2C19MAPT | |
| SCHEMBL27993371 | 0.69 | KDM4E (0.43) | MEN1KMT2AMAPTALDH1A1GAA | |
| SCHEMBL25170294 | 0.69 | KDM4E (0.42) | HDAC6HDAC1MAPTALDH1A1USP2 | |
| SCHEMBL20328549 | 0.68 | KDM4E (0.42) | MEN1KMT2ACYP1A2CYP2C19MAPT | |
| SCHEMBL24129828 | 0.67 | MAPT (0.50) | MEN1KMT2AMAPTALDH1A1TSHR | |
| SCHEMBL31336087 | 0.67 | HSD17B10 (0.56) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL29016434 | 0.67 | KDM4E (0.43) | HDAC6HDAC1MAPTALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1144369-B1 | ACETYLENIC ARYL SULFONAMIDE AND PHOSPHINIC ACID AMIDE HYDROXAMIC ACID TACE INHIBITORS | WYETH CORP (US) | 2004-07-21 | — | — | EP | claimed |