Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 14/20 | 0.54 |
| ▸ | PDE4A | P27815 | 13/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.54 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4696721 | 0.90 | KDM4E (0.58) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL1013113 | 0.86 | MAPT (0.50) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL6822446 | 0.83 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1030765 | 0.83 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL1029279 | 0.83 | PDE4A (0.59) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL29440119 | 0.81 | PDE4A (0.54) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL142851 | 0.81 | PDE4D (0.54) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL184260 | 0.81 | PDE4B (0.70) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL31614784 | 0.80 | PDE4A (0.52) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL8890021 | 0.79 | PDE4B (0.62) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004022536-A1 | NEW HETEROCYCLIC AMIDE COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LIMITED (US) | 2004-03-18 | — | — | WO | disclosed |