Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 17/20 | 0.64 |
| ▸ | RARB | P10826 | 17/20 | 0.64 |
| ▸ | RARG | P13631 | 16/20 | 0.64 |
| ▸ | RXRA | P19793 | 1/20 | 0.64 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6810969 | 0.88 | RARA (0.50) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8028110 | 0.86 | RARA (0.58) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6293941 | 0.84 | RARA (0.64) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6293940 | 0.84 | RARA (0.64) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6294021 | 0.83 | RARA (0.69) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6294022 | 0.83 | RARA (0.69) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6816012 | 0.83 | RARB (0.52) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8032218 | 0.83 | RARA (0.68) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL8026328 | 0.81 | RARA (0.72) | RARARARBRARGRXRANR2E1 | |
| SCHEMBL6294007 | 0.79 | RARA (0.63) | RARARARBRARGRXRANR2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115687-B1 | 5,6-DIHYDRONAPHTHALENYL DERIVATIVES HAVING RETINOID-LIKE ACTIVITY | BRISTOL MYERS SQUIBB CO (US) | 2004-05-26 | — | — | EP | disclosed |
| US-6194601-B1 | USEFUL IN TREATMENT OF SKIN DISORDERS SUCH AS ACNE AND DAMAGE FROM AGE OR IRRADIATION; CHRONIC SKIN INFLAMMATORY INFLAMMATORY DISEASES SUCH AS PSORIASIS AND ATOPIC DERMATITIS; ANTITUMOR AGENTS FOR BREAST CANCER, LUNG CANCER; NONTOXIC | BRISTOL-MYERS SQUIBB COMPANY | 2001-02-27 | — | — | US | disclosed |