Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.80 |
| ▸ | PSMB1 | P20618 | 6/20 | 0.71 |
| ▸ | PSMB5 | P28074 | 6/20 | 0.71 |
| ▸ | PSMB2 | P49721 | 6/20 | 0.71 |
| ▸ | LTA4H | P09960 | 7/20 | 0.64 |
| ▸ | ESR1 | P03372 | 1/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL227588 | 0.97 | HRH3 (0.85) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| SCHEMBL224627 | 0.97 | HRH3 (0.85) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| SCHEMBL8973201 | 0.95 | HRH3 (0.82) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| SCHEMBL4089206 | 0.89 | HRH3 (1.00) | HRH3 | |
| SCHEMBL6657187 | 0.84 | HRH3 (0.86) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| SCHEMBL12128339 | 0.84 | HRH3 (0.85) | HRH3 | |
| SCHEMBL224640 | 0.84 | PSMB1 (0.76) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| SCHEMBL17826374 | 0.84 | PSMB1 (0.71) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| SCHEMBL9056254 | 0.83 | HRH3 (0.83) | HRH3PSMB1PSMB5PSMB2LTA4H | |
| SCHEMBL3580727 | 0.82 | HRH3 (1.00) | HRH3PSMB1PSMB5PSMB2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1159267-B1 | N-SUBSTITUTED INDOLINES AS ESTROGENIC AGENTS | WYETH CORP (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6358943-B1 | TREATMENT OF OSTEOPOROSIS, BENIGN PROSTATIC HYPERPLASIA, BREAST AND/OR ENDOMETRIAL CANCER | AMERICAN HOME PRODUCTS CORPORATION | 2002-03-19 | — | — | US | disclosed |
| EP-1159267-A1 | N-SUBSTITUTED INDOLINES AS ESTROGENIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-12-05 | — | — | EP | disclosed |
| WO-2000051982-A1 | N-SUBSTITUTED INDOLINES AS ESTROGENIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-09-08 | — | — | WO | disclosed |