Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.81 |
| ▸ | MEN1 | O00255 | 5/20 | 0.81 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.81 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.81 |
| ▸ | GRK6 | P43250 | 1/20 | 0.75 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.74 |
| ▸ | AR | P10275 | 2/20 | 0.73 |
| ▸ | ESR1 | P03372 | 1/20 | 0.72 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.72 |
| ▸ | PLK1 | P53350 | 1/20 | 0.72 |
| ▸ | MASP2 | O00187 | 1/20 | 0.68 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.68 |
| ▸ | CD44 | P16070 | 1/20 | 0.68 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.68 |
| ▸ | MSN | P26038 | 1/20 | 0.68 |
| ▸ | CDC25B | P30305 | 1/20 | 0.68 |
| ▸ | AKT1 | P31749 | 1/20 | 0.68 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.68 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23949811 | 1.00 | MAPT (0.81) | MAPTMEN1KMT2AKDM4EGRK6 | |
| SCHEMBL14582287 | 0.91 | KMT2A (0.80) | MAPTMEN1KMT2AKDM4EGRK6 | |
| SCHEMBL17464587 | 0.90 | MAPT (0.76) | MAPTMEN1KMT2AKDM4EGRK6 | |
| SCHEMBL23950052 | 0.90 | MAPT (0.76) | MAPTMEN1KMT2AKDM4EGRK6 | |
| SCHEMBL17458830 | 0.90 | MAPT (0.76) | MAPTMEN1KMT2AKDM4EGRK6 | |
| SCHEMBL23949812 | 0.90 | MAPT (0.76) | MAPTMEN1KMT2AKDM4EGRK6 | |
| SCHEMBL23949489 | 0.90 | MAPT (0.76) | MAPTMEN1KMT2AKDM4EGRK6 | |
| SCHEMBL23949922 | 0.89 | NR4A1 (0.72) | MAPTMEN1KMT2AKDM4EGRK6 | |
| SCHEMBL15300108 | 0.88 | GRK6 (0.74) | MAPTMEN1KMT2AKDM4EGRK6 | |
| SCHEMBL13601355 | 0.88 | AR (0.79) | MAPTMEN1KMT2AKDM4EGRK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010233-A1 | METHODS AND COMPOSITIONS TO INHIBIT EDEMA FACTOR AND ADENYLYL CYCLASE | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS (US) | 2012-01-12 | — | — | US | disclosed |
| US-8003692-B2 | Methods and compositions to inhibit edema factor and adenylyl cyclase | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2011-08-23 | — | — | US | disclosed |
| US-20090093519-A1 | Methods and Compositions to Inhibit Edema Factor and Adenylyl Cyclase | MISSION PHARMACAL CO. (US) | 2009-04-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090093519-A1 | Methods and Compositions to Inhibit Edema Factor and Adenylyl Cyclase | VIP, PDE3B, ADCY5 | MAPT 4872/4885MEN1 3097/4885KMT2A 4847/4885 |
| US-20120010233-A1 | METHODS AND COMPOSITIONS TO INHIBIT EDEMA FACTOR AND ADENYLYL CYCLASE | VIP, PDE3B, ADCY5 | MAPT 4872/4885MEN1 3097/4885KMT2A 4847/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.