Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.42 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | APAF1 | O14727 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6816898 | 0.87 | CSNK2A1 (0.50) | MAPTMEN1KMT2AGAAPOLB | |
| SCHEMBL29116821 | 0.86 | CSNK2A1 (0.56) | MAPTMEN1KMT2AGAAPOLB | |
| SCHEMBL30669533 | 0.86 | CSNK2A1 (0.56) | MAPTMEN1KMT2AGAAPOLB | |
| SCHEMBL2172029 | 0.76 | CSNK2A1 (0.50) | MAPTMEN1KMT2AGAAPOLB | |
| SCHEMBL7087257 | 0.73 | MAPT (0.59) | MAPTMEN1KMT2AGAAPOLB | |
| SCHEMBL7087262 | 0.73 | MAPT (0.47) | MAPTMEN1KMT2AGAAPOLB | |
| SCHEMBL2170731 | 0.70 | PDE4B (0.53) | MAPTMEN1KMT2AGAAPOLB | |
| SCHEMBL1663645 | 0.69 | MEN1 (0.97) | MAPTMEN1KMT2AGAAPOLB | |
| SCHEMBL6816721 | 0.68 | HTT (0.47) | MAPTMEN1KMT2AGAATDP1 | |
| SCHEMBL7865623 | 0.68 | HTT (0.47) | MAPTMEN1KMT2AGAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185265-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-1185265-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| US-6300325-B1 | HETEROCYCLIC RECEPTOR ANTAGONIST | SMITHKLINE BEECHAM CORPORATION | 2001-10-09 | — | — | US | disclosed |
| WO-2000076501-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |
| EP-0991406-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2000-12-13 | — | — | EP | disclosed |
| EP-0991406-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-04-12 | — | — | EP | disclosed |
| WO-1998032439-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-07-30 | — | — | WO | disclosed |