Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817295 | 1.00 | KHK (0.34) | KHKCHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6817271 | 1.00 | KHK (0.34) | KHKCHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6812558 | 1.00 | KHK (0.34) | KHKCHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6821429 | 1.00 | KHK (0.34) | KHKCHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6813249 | 0.95 | MEN1 (0.33) | KHKCHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6820969 | 0.95 | MEN1 (0.33) | KHKCHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6813254 | 0.95 | MEN1 (0.33) | KHKCHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6821406 | 0.92 | — | — | |
| SCHEMBL6821403 | 0.92 | — | — | |
| SCHEMBL6816920 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004009599-A1 | FIVE-MEMBERED HETEROAROMATIC OLEFINIC AZACYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS INHIBITORS OF NCOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2004-01-29 | — | — | WO | disclosed |
| US-20020160998-A1 | Pharmaceutical compositions and methods for use | TARGACEPT, INC. | 2002-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020160998-A1 | Pharmaceutical compositions and methods for use | AADAC, CYP3A7, CYP3A5 | KHK 1353/4885CHRNB2 710/4885CHRNA4 346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.