Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817365 | 1.00 | MAPK1 (0.49) | MAPK1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6817328 | 0.92 | MAPT (0.44) | MAPK1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2196461 | 0.90 | MAPK1 (0.47) | MAPK1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL2196464 | 0.90 | MAPK1 (0.47) | MAPK1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6817261 | 0.88 | MAPK1 (0.54) | MAPK1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6817260 | 0.88 | MAPK1 (0.54) | MAPK1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6813196 | 0.87 | MAPK1 (0.55) | MAPK1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6813206 | 0.87 | MAPK1 (0.55) | MAPK1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6821134 | 0.86 | MAPK13 (0.61) | MAPK1MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6818058 | 0.86 | MAPK13 (0.56) | MAPK1MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210320-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | disclosed |
| US-6566554-B1 | Including amino benzothiophenones; useful for treatment of inflammatory diseases in which the production of cytokines is involved in the pathogenesis | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2003-05-20 | — | — | US | disclosed |