SCHEMBL6817375

SCHEMBL6817375

COc1ccc(Sc2sc(S(=O)(=O)Nc3ccc(C(F)(F)F)c(O[C@@H]4CCN(C)C4)c3)cc2Br)cc1OC

nearest known ligand 0.69

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 19/20 0.69
LMNA P02545 1/20 0.42
HTT P42858 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6817380 1.00 UTS2R (0.69) UTS2RLMNAHTTSMN1; SMN2
SCHEMBL6821390 0.90 UTS2R (0.61) UTS2RHTT
SCHEMBL6821383 0.90 UTS2R (0.61) UTS2RHTT
SCHEMBL6820786 0.90 UTS2R (0.62) UTS2RSMN1; SMN2
SCHEMBL6820784 0.90 UTS2R (0.62) UTS2RSMN1; SMN2
SCHEMBL6821343 0.90 UTS2R (0.62) UTS2RSMN1; SMN2
SCHEMBL6821337 0.90 UTS2R (0.62) UTS2RSMN1; SMN2
SCHEMBL6820769 0.90 UTS2R (0.63) UTS2RLMNA
SCHEMBL6820771 0.90 UTS2R (0.63) UTS2RLMNA
SCHEMBL6817494 0.89 UTS2R (0.60) UTS2RLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO claimed
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed