SCHEMBL6820769

SCHEMBL6820769

COc1cccc(Sc2sc(S(=O)(=O)Nc3ccc(C(F)(F)F)c(O[C@@H]4CCN(C)C4)c3)cc2Br)c1

nearest known ligand 0.63

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
UTS2R Q9UKP6 18/20 0.63
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
PKM P14618 1/20 0.38
KMT2A Q03164 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6820771 1.00 UTS2R (0.63) UTS2RMEN1LMNAPKMKMT2A
SCHEMBL6823500 0.91 UTS2R (0.60) UTS2R
SCHEMBL6823511 0.91 UTS2R (0.60) UTS2R
SCHEMBL6817375 0.90 UTS2R (0.69) UTS2RLMNA
SCHEMBL6817380 0.90 UTS2R (0.69) UTS2RLMNA
SCHEMBL6817488 0.90 UTS2R (0.60) UTS2RLMNA
SCHEMBL6817494 0.90 UTS2R (0.60) UTS2RLMNA
SCHEMBL8339676 0.89 UTS2R (0.59) UTS2RMEN1LMNAPKMKMT2A
SCHEMBL6821390 0.87 UTS2R (0.61) UTS2R
SCHEMBL6821383 0.87 UTS2R (0.61) UTS2R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO claimed
WO-2004043917-A1 SULFONAMIDES SMITHKLINE BEECHAM CORPORATION (US) 2004-05-27 WO disclosed