Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.58 |
| ▸ | MAPK13 | O15264 | 10/20 | 0.58 |
| ▸ | MAPK12 | P53778 | 10/20 | 0.58 |
| ▸ | MAPK11 | Q15759 | 10/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 1/20 | 0.38 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817660 | 0.90 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL6820921 | 0.82 | MAPK14 (0.61) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL6813027 | 0.81 | MAPK14 (0.60) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL6813199 | 0.81 | MAPK14 (0.56) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6817357 | 0.79 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL7075394 | 0.79 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL5174459 | 0.79 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL6817162 | 0.78 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11ALDH1A1 | |
| SCHEMBL1906857 | 0.78 | MAPK14 (0.64) | MAPK14MAPK13MAPK12MAPK11AVPR2 | |
| SCHEMBL6817560 | 0.78 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1210320-B1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMA AS (DK) | 2004-09-29 | — | — | EP | disclosed |
| US-6566554-B1 | Including amino benzothiophenones; useful for treatment of inflammatory diseases in which the production of cytokines is involved in the pathogenesis | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2003-05-20 | — | — | US | disclosed |
| EP-1210320-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1BETA AND TNF-ALPHA | LEO PHARMACEUTICAL PRODUCTS LTD. A/S (LOVENS KEMISKE FABRIK PRODUKTIONSAKTIESELSKAB) (DK) | 2002-06-05 | — | — | EP | disclosed |
| WO-2001005746-A1 | AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a) | Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) | 2001-01-25 | — | — | WO | disclosed |