SCHEMBL6817645

SCHEMBL6817645

COC(=O)Nc1ccc(OC)c(-c2cc3c(C(=O)Nc4ccc(C#N)cc4C(=O)O)noc3cc2NC(C)=O)c1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AGPAT2 O15120 1/20 0.37
HIF1A Q16665 3/20 0.36
ALDH1A1 P00352 1/20 0.36
HTR2A P28223 1/20 0.35
HTR2C P28335 1/20 0.35
TP53 P04637 1/20 0.35
POLB P06746 1/20 0.35
MAPT P10636 1/20 0.35
ALB P02768 2/20 0.34
LRRK2 Q5S007 2/20 0.33
EIF4EBP1 Q13541 1/20 0.33
ABL1 P00519 1/20 0.33
RIN1 Q13671 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
CHEK1 O14757 1/20 0.33
TUBB4A P04350 1/20 0.33
TUBB P07437 1/20 0.33
TUBA3C P0DPH7 1/20 0.33
TUBA1B P68363 1/20 0.33
TUBA4A P68366 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6813726 0.98 AGPAT2 (0.37) AGPAT2HIF1AALDH1A1HTR2AHTR2C
SCHEMBL6819127 0.96 ALDH1A1 (0.39) HIF1AALDH1A1HTR2AHTR2CTP53
SCHEMBL6819666 0.95 ALDH1A1 (0.38) AGPAT2HIF1AALDH1A1HTR2AHTR2C
SCHEMBL6817347 0.94 ALDH1A1 (0.40) HIF1AALDH1A1HTR2AHTR2CTP53
SCHEMBL6822192 0.92 AGPAT2 (0.35) AGPAT2HIF1AALDH1A1HTR2AHTR2C
SCHEMBL6813822 0.92 AGPAT2 (0.37) AGPAT2HIF1AHTR2AHTR2CTP53
SCHEMBL6818713 0.90 EGLN2 (0.37) AGPAT2HIF1ATP53POLBMAPT
SCHEMBL6818523 0.89 ALDH1A1 (0.43) HIF1AALDH1A1HTR2AHTR2CTP53
SCHEMBL6818846 0.89 ALDH1A1 (0.39) HIF1AALDH1A1HTR2AHTR2CTP53
SCHEMBL6821197 0.89 ALDH1A1 (0.39) HIF1AALDH1A1HTR2AHTR2CTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004018428-A1 ANTIBACTERIAL BENZOIC ACID DERIVATIVES PHARMACIA & UPJOHN COMPANY LLC (US) 2004-03-04 WO disclosed