Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.70 |
| ▸ | PDE4A | P27815 | 18/20 | 0.70 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.70 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6546827 | 0.96 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6546830 | 0.96 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6546876 | 0.96 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6546469 | 0.95 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6546476 | 0.95 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6546903 | 0.95 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL13350287 | 0.87 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL8326534 | 0.87 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6199802 | 0.86 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL5799817 | 0.86 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1051172-B1 | METHOD FOR TREATING COPD | SMITHKLINE BEECHAM CORP (US) | 2004-12-22 | — | — | EP | disclosed |
| US-6369108-B1 | CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD). | SMITHKLINE BEECHAM CORPORATION | 2002-04-09 | — | — | US | disclosed |