Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.63 |
| ▸ | PDE4A | P27815 | 15/20 | 0.63 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13350287 | 1.00 | PDE4B (0.63) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL6546827 | 0.91 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6546830 | 0.91 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6546876 | 0.91 | PDE4B (0.67) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7855467 | 0.89 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL7855470 | 0.89 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6546903 | 0.88 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6546469 | 0.88 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6546476 | 0.88 | PDE4B (0.76) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL6817819 | 0.87 | PDE4B (0.70) | PDE4BPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1849468-A2 | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | Nycomed GmbH (DE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2004047817-A1 | PDE4 AND PDE3/4 INHIBITORS FOR USE IN THE TREATMENT OF CACHEXIA | ALTANA PHARMA AG (DE) | 2004-06-10 | — | — | WO | disclosed |
| WO-2003024488-A2 | COMBINATION OF A PDE INHIBITOR AND A LEUKOTRIENE RECEPTOR ANTAGONIST | ALTANA PHARMA AG (DE) | 2003-03-27 | — | — | WO | disclosed |