Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 7/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 3/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CCND1 | P24385 | 2/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1711142 | 0.87 | EP300 (0.45) | PARP1PTPN1CA1CA2CDK2 | |
| SCHEMBL165110 | 0.84 | PDK2 (0.40) | PARP1PTPN1CA1CA2GAA | |
| SCHEMBL30125362 | 0.84 | PDK2 (0.40) | PARP1PTPN1CA1CA2GAA | |
| SCHEMBL163723 | 0.83 | GSK3B (0.35) | PARP1PTPN1GSK3BCDK4CCND1 | |
| SCHEMBL30125565 | 0.81 | MEN1 (0.34) | PARP1PTPN1GAAMEN1POLB | |
| SCHEMBL1816046 | 0.81 | TTR (0.34) | PARP1PTPN1GAAMEN1POLB | |
| SCHEMBL27082851 | 0.81 | MEN1 (0.34) | PARP1PTPN1GAAMEN1POLB | |
| SCHEMBL1815597 | 0.81 | KCNH2 (0.36) | PARP1PTPN1GSK3BGAAMEN1 | |
| SCHEMBL6814281 | 0.81 | GSK3B (0.37) | CA1CA2CA7CA9GSK3B | |
| SCHEMBL1010811 | 0.80 | EGFR (0.38) | CDK4CCND1CCNA2CDK2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1214311-B1 | NOVEL INDENO-FUSED PHOTOCHROMIC NAPHTHOPYRANS | TRANSITIONS OPTICAL INC (US) | 2004-09-15 | — | — | EP | disclosed |
| US-6296785-B1 | OPHTHALMIC AND CONTACT LENSES; WINDOWS, SAFETY GLASS FOR CARS | PPG INDUSTRIES OHIO, INC. | 2001-10-02 | — | — | US | disclosed |